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dc.contributor.authorFrentz, Dineke
dc.contributor.authorWensing, Annemarie M J
dc.contributor.authorAlbert, Jan
dc.contributor.authorParaskevis, Dimitrios
dc.contributor.authorAbecasis, Ana B
dc.contributor.authorHamouda, Osamah
dc.contributor.authorJørgensen, Louise B
dc.contributor.authorKücherer, Claudia
dc.contributor.authorStruck, Daniel
dc.contributor.authorSchmit, Jean-Claude
dc.contributor.authorÅsjö, Birgitta
dc.contributor.authorBalotta, Claudia
dc.contributor.authorBeshkov, Danail
dc.contributor.authorCamacho, Ricardo J
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorCoughlan, Suzie
dc.contributor.authorDe Wit, Stéphane
dc.contributor.authorGriskevicius, Algirdas
dc.contributor.authorGrossman, Zehava
dc.contributor.authorHorban, Andrzej
dc.contributor.authorKolupajeva, Tatjana
dc.contributor.authorKorn, Klaus
dc.contributor.authorKostrikis, Leondios G
dc.contributor.authorLiitsola, Kirsi
dc.contributor.authorLinka, Marek
dc.contributor.authorNielsen, Claus
dc.contributor.authorOtelea, Dan
dc.contributor.authorParedes, Roger
dc.contributor.authorPoljak, Mario
dc.contributor.authorPuchhammer-Stöckl, Elisabeth
dc.contributor.authorSönnerborg, Anders
dc.contributor.authorStanekova, Danica
dc.contributor.authorStanojevic, Maja
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorBoucher, Charles A B
dc.contributor.authorVan de Vijver, David A M C
dc.contributor.authorSPREAD Programme
dc.date.accessioned2013-04-15T14:22:38Z
dc.date.available2013-04-15T14:22:38Z
dc.date.issued2013-04-03
dc.identifier.citationRetrovirology. 2013 Apr 03;10(1):36en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-10-36
dc.identifier.urihttp://hdl.handle.net/10147/281354
dc.description.abstractAbstract Background International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002–2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045). Conclusions Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.
dc.language.isoenen
dc.subjectHIV INFECTIONen_GB
dc.subjectINFECTION CONTROLen_GB
dc.titleLimited cross-border infections in patients newly diagnosed with HIV in Europeen_GB
dc.language.rfc3066en
dc.rights.holderDineke Frentz et al.; licensee BioMed Central Ltd.
dc.description.statusPeer Reviewed
dc.date.updated2013-04-12T11:03:28Z
refterms.dateFOA2018-08-23T04:35:28Z
html.description.abstractAbstract Background International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe. Results Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002&#8211;2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value &lt;0.0001), in men who have sex with men (P-value &lt;0.0001), and in recently infected patients (P-value =0.045). Conclusions Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.


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