Issue Date
2020-02-05Keywords
Crohn’s diseaseINFLAMMATORY BOWEL DISEASE
ulcerative colitis
Metadata
Show full item recordJournal
Therapeutic advances in chronic diseaseDOI
10.1177/2040622319899297PubMed ID
32076497Additional Links
https://journals.sagepub.com/doi/10.1177/2040622319899297?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govAbstract
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation, a relapsing and remitting clinical course, requirement for lifelong medication and often, significant morbidity. While multiple effective therapeutic options exist for the treatment of IBD, a proportion of patients will either fail to respond or lose response to therapy. Advances in therapeutics, such as the gut-specific anti-integrins, now offer patients an alternative option to systemic immunosuppression. Anti-interleukin 12 (anti-IL-12)/IL-23 agents offer new and effective treatment options for CD, while the oral small molecules now offer an oral alternative for the treatment of moderate-to-severe disease, previously requiring subcutaneous injection or intravenous infusion. Alternatives to pharmacological treatment such as stem-cell transplant and faecal microbiota transplant are also showing some promise in the treatment of both CD and UC.Item Type
ArticleOther
Language
enISSN
2040-6223ae974a485f413a2113503eed53cd6c53
10.1177/2040622319899297
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