Show simple item record

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles.

dc.contributor.authorFernandez Alarcon, Jennifer
dc.contributor.authorPerez Schmidt, Patricia
dc.contributor.authorPanini, Nicolo
dc.contributor.authorCaruso, Francesca
dc.contributor.authorViolatto, Martina B
dc.contributor.authorSukubo, Naths Grazia
dc.contributor.authorMartinez-Serra, Alberto
dc.contributor.authorEkalle-Soppo, Charlotte Blanche
dc.contributor.authorMorelli, Annalisa
dc.contributor.authorMoscatiello, Giulia Yuri
dc.contributor.authorGrasselli, Chiara
dc.contributor.authorCorbelli, Alessandro
dc.contributor.authorFiordaliso, Fabio
dc.contributor.authorKelk, Joe
dc.contributor.authorPetrosilli, Laura
dc.contributor.authord'Orazio, Giuseppe
dc.contributor.authorMateu Ferrando, Ruth
dc.contributor.authorVerdaguer Ferrer, Ariadna
dc.contributor.authorFornaguera, Cristina
dc.contributor.authorLay, Luigi
dc.contributor.authorFumagalli, Stefano
dc.contributor.authorRecchia, Sandro
dc.contributor.authorMonopoli, Marco P
dc.contributor.authorPolito, Laura
dc.contributor.authorBigini, Paolo
dc.contributor.authorSitia, Giovanni
dc.date.accessioned2025-06-10T10:49:07Z
dc.date.available2025-06-10T10:49:07Z
dc.date.issued2025-02-14
dc.identifier.citationFernandez Alarcon J, Perez Schmidt P, Panini N, Caruso F, Violatto MB, Sukubo NG, Martinez-Serra A, Ekalle-Soppo CB, Morelli A, Moscatiello GY, Grasselli C, Corbelli A, Fiordaliso F, Kelk J, Petrosilli L, d'Orazio G, Mateu Ferrando R, Verdaguer Ferrer A, Fornaguera C, Lay L, Fumagalli S, Recchia S, Monopoli MP, Polito L, Bigini P, Sitia G. Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles. Adv Sci (Weinh). 2025 Apr;12(16):e2407458. doi: 10.1002/advs.202407458. Epub 2025 Feb 14. PMID: 39950558; PMCID: PMC12021048.en_US
dc.identifier.pmid39950558
dc.identifier.doi10.1002/advs.202407458
dc.identifier.urihttp://hdl.handle.net/10147/645293
dc.descriptionMacrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity or trigger anti‐inflammatory immunity. Glycans have emerged as key components for immunity as they are involved in many pathophysiological disorders. Previous studies have demonstrated that supraphysiological amounts of mannose (Man) or sialic acid (Sia) can inhibit tumor growth and stimulate differentiation of regulatory T cells. Man is known to affect glucose metabolism in glycolysis by competing for the same intracellular transporters and affecting macrophage polarization, whereas Sia alters macrophage differentiation via signaling through Siglec‐1. Herein, this work describes a macrophage targeting platform using gold nanoparticles (GNPs) functionalized with Man and Sia monosaccharides which exhibit high liver tropism. A single dose of glyco‐GNPs can convert macrophages to a restorative phenotype in two completely different immune environments. Man promotes tumor‐associated macrophages toward an antitumorigenic activity in a MC38 liver colorectal cancer model by secretion of TNF‐α, IL ‐1β, and IL ‐6 in the tumor microenvironment. However, in a proinflammatory environment, as observed in a mouse model of autoimmune disease, primary biliary cholangitis, Man impairs the production of TNF‐α, IL‐1β, Arg1, and IL‐6 cytokines. The results probe the dual role of Man in macrophage repolarization in response to the immune system. This study is a proof‐of‐concept that demonstrates that nanomedicine using specific glycans designed to target other immune cells such as myeloid cells, are a promising strategy not only against cancer but also against other pathologies such as autoimmune diseases.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rights© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectglycansen_US
dc.subjectgold nanoparticlesen_US
dc.subjecthepatic metastasesen_US
dc.subjectIMMUNOTHERAPYen_US
dc.subjectprimary biliary cholangitisen_US
dc.titleFunctional Polarization of Liver Macrophages by Glyco Gold Nanoparticles.en_US
dc.typeArticleen_US
dc.identifier.eissn2198-3844
dc.identifier.journalAdvanced science (Weinheim, Baden-Wurttemberg, Germany)en_US
dc.identifier.pmcidPMC12021048
dc.source.journaltitleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)
dc.source.volume12
dc.source.issue16
dc.source.beginpagee2407458
dc.source.endpage
refterms.dateFOA2025-06-10T10:49:09Z
dc.source.countryGermany


Files in this item

Thumbnail
Name:
PMC12021048.pdf
Size:
6.758Mb
Format:
PDF
Download

This item appears in the following Collection(s)

Show simple item record

© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
Except where otherwise noted, this item's license is described as © 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.