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International Severe Asthma Registry (ISAR): 2017-2024 Status and Progress Update.

dc.contributor.authorLarenas-Linnemann, Désirée
dc.contributor.authorRhee, Chin Kook
dc.contributor.authorAltraja, Alan
dc.contributor.authorBusby, John
dc.contributor.authorTran, Trung N
dc.contributor.authorWang, Eileen
dc.contributor.authorPopov, Todor A
dc.contributor.authorMitchell, Patrick D
dc.contributor.authorPfeffer, Paul E
dc.contributor.authorPleasants, Roy Alton
dc.contributor.authorKatial, Rohit
dc.contributor.authorKoh, Mariko Siyue
dc.contributor.authorBourdin, Arnaud
dc.contributor.authorSchleich, Florence
dc.contributor.authorMáspero, Jorge
dc.contributor.authorHew, Mark
dc.contributor.authorPeters, Matthew J
dc.contributor.authorJackson, David J
dc.contributor.authorChristoff, George C
dc.contributor.authorPerez-de-Llano, Luis
dc.contributor.authorCherrez-Ojeda, Ivan
dc.contributor.authorFonseca, João A
dc.contributor.authorCostello, Richard W
dc.contributor.authorTorres-Duque, Carlos A
dc.contributor.authorKuna, Piotr
dc.contributor.authorMenzies-Gow, Andrew N
dc.contributor.authorStjepanovic, Neda
dc.contributor.authorGibson, Peter G
dc.contributor.authorPitrez, Paulo Márcio
dc.contributor.authorBergeron, Celine
dc.contributor.authorPorsbjerg, Celeste M
dc.contributor.authorTaillé, Camille
dc.contributor.authorTaube, Christian
dc.contributor.authorPapadopoulos, Nikolaos G
dc.contributor.authorPapaioannou, Andriana I
dc.contributor.authorSalvi, Sundeep
dc.contributor.authorCanonica, Giorgio Walter
dc.contributor.authorHeffler, Enrico
dc.contributor.authorIwanaga, Takashi
dc.contributor.authorAl-Ahmad, Mona S
dc.contributor.authorLehmann, Sverre
dc.contributor.authorAl-Lehebi, Riyad
dc.contributor.authorCosio, Borja G
dc.contributor.authorPerng, Diahn-Warng
dc.contributor.authorMahboub, Bassam
dc.contributor.authorHeaney, Liam G
dc.contributor.authorPatel, Pujan H
dc.contributor.authorLugogo, Njira
dc.contributor.authorWechsler, Michael E
dc.contributor.authorBulathsinhala, Lakmini
dc.contributor.authorCarter, Victoria
dc.contributor.authorFletton, Kirsty
dc.contributor.authorNeil, David L
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorPrice, David B
dc.date.accessioned2025-06-10T10:50:18Z
dc.date.available2025-06-10T10:50:18Z
dc.date.issued2025-02-06
dc.identifier.citationLarenas-Linnemann D, Rhee CK, Altraja A, Busby J, Tran TN, Wang E, Popov TA, Mitchell PD, Pfeffer PE, Pleasants RA, Katial R, Koh MS, Bourdin A, Schleich F, Máspero J, Hew M, Peters MJ, Jackson DJ, Christoff GC, Perez-de-Llano L, Cherrez-Ojeda I, Fonseca JA, Costello RW, Torres-Duque CA, Kuna P, Menzies-Gow AN, Stjepanovic N, Gibson PG, Pitrez PM, Bergeron C, Porsbjerg CM, Taillé C, Taube C, Papadopoulos NG, Papaioannou AI, Salvi S, Canonica GW, Heffler E, Iwanaga T, Al-Ahmad MS, Lehmann S, Al-Lehebi R, Cosio BG, Perng DW, Mahboub B, Heaney LG, Patel PH, Lugogo N, Wechsler ME, Bulathsinhala L, Carter V, Fletton K, Neil DL, Scelo G, Price DB. International Severe Asthma Registry (ISAR): 2017-2024 Status and Progress Update. Tuberc Respir Dis (Seoul). 2025 Apr;88(2):193-215. doi: 10.4046/trd.2024.0198. Epub 2025 Feb 6. PMID: 39915034; PMCID: PMC12010726.en_US
dc.identifier.issn1738-3536
dc.identifier.pmid39915034
dc.identifier.doi10.4046/trd.2024.0198
dc.identifier.urihttp://hdl.handle.net/10147/645294
dc.descriptionThe International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As the first global registry for adults with severe asthma, ISAR enabled individual registries to standardize and pool their data, creating a comprehensive, harmonized dataset with sufficient statistical power to address key research questions and knowledge gaps. Today, ISAR is the largest repository of real-world data on severe asthma, curating data on nearly 35,000 patients from 28 countries worldwide, and has become a leading contributor to severe asthma research. Research using ISAR data has provided valuable insights on the characteristics of severe asthma, its burdens and risk factors, real-world treatment effectiveness, and barriers to specialist care, which are collectively informing improved asthma management. Besides changing clinical thinking via research, ISAR aims to advance real-world practice through initiatives that improve registry data quality and severe asthma care. In 2024, ISAR refined essential research variables to enhance data quality and launched a web-based data acquisition and reporting system (QISAR), which integrates data collection with clinical consultations and enables longitudinal data tracking at patient, center, and population levels. Quality improvement priorities include collecting standardized data during consultations and tracking and optimizing patient journeys via QISAR and integrating primary/secondary care pathways to expedite specialist severe asthma management and facilitate clinical trial recruitment. ISAR envisions a future in which timely specialist referral and initiation of biologic therapy can obviate long-term systemic corticosteroid use and enable more patients to achieve remission.en_US
dc.language.isoenen_US
dc.publisherTuberculosis and Respiratory Diseasesen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCore Variablesen_US
dc.subjectDelphi Consensusen_US
dc.subjectInternational Severe Asthma Registry (ISAR)en_US
dc.subjectOptimum Patient Care Globalen_US
dc.subjectQuality Improvementen_US
dc.subjectReal-World Dataen_US
dc.titleInternational Severe Asthma Registry (ISAR): 2017-2024 Status and Progress Update.en_US
dc.typeArticleen_US
dc.identifier.journalTuberculosis and respiratory diseasesen_US
dc.identifier.pmcidPMC12010726
dc.source.journaltitleTuberculosis and respiratory diseases
dc.source.volume88
dc.source.issue2
dc.source.beginpage193
dc.source.endpage215
refterms.dateFOA2025-06-10T10:50:21Z
dc.source.countryKorea (South)


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International