• H.E.A.R Powerpoint Presentation

      Carrigan, Marie (Carrigan, Marie, 2016-10)
    • H1N1 and vaccination of rheumatology patients.

      O'Connor, M B; Phelan, M J (2011-05)
    • H1N1 virus and vaccination among rheumatology patients, especially those on DMARDS.

      O'Connor, M B; Rathi, J; Bond, U; Swan, J; Phelan, M (2010-04)
    • H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast

      Shieh, Grace S.; Pan, Chin-Hua; Wu, Jia-Hong; Sun, Yun-Ju; Wang, Chia-Chang; Hsiao, Wei-Chun; Lin, Chia-Yeh; Tung, Luh; Chang, Tien-Hsien; Fleming, Alastair B.; et al. (2011-12-22)
      Abstract Background The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional splicing of pre-mRNA. Results Here we provide evidence that H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae. A genome-wide map of H2BK123ub1 in this organism reveals that this modification is enriched in coding regions and that its levels peak at the transcribed regions of two characteristic subgroups of genes. First, long genes are more likely to have higher levels of H2BK123ub1, correlating with the postulated role of this modification in preventing cryptic transcription initiation in ORFs. Second, genes that are highly transcribed also have high levels of H2BK123ub1, including the ribosomal protein genes, which comprise the majority of intron-containing genes in yeast. H2BK123ub1 is also a feature of introns in the yeast genome, and the disruption of this modification alters the intragenic distribution of H3 trimethylation on lysine 36 (H3K36me3), which functionally correlates with alternative RNA splicing in humans. In addition, the deletion of genes encoding the U2 snRNP subunits, Lea1 or Msl1, in combination with an htb-K123R mutation, leads to synthetic lethality. Conclusion These data suggest that H2BK123ub1 facilitates cross talk between chromatin and pre-mRNA splicing by modulating the distribution of intronic and exonic histone modifications.
    • Haemodynamic performance of neuromuscular electrical stimulation (NMES) during recovery from total hip arthroplasty

      Broderick, Barry J; Breathnach, Oisin; Condon, Finbarr; Masterson, Eric; ÓLaighin, Gearóid (2013-03-05)
      Abstract Background Patients post total hip arthroplasty (THA) remain at high risk of developing Deep Vein Thrombosis (DVT) during the recovery period following surgery despite the availability of effective pharmacological and mechanical prophylactic methods. The use of calf muscle neuromuscular electrical stimulation (NMES) during the hospitalised recovery period on this patient group may be effective at preventing DVT. However, the haemodynamic effectiveness and comfort characteristics of NMES in post-THA patients immediately following surgery have yet to be established. Methods The popliteal veins of 11 patients, who had undergone unilateral total hip replacement surgery on the day previous to the study, were measured using Doppler ultrasound during a 4 hour neuromuscular electrical stimulation (NMES) session of the calf muscles. The effect of calf muscle NMES on peak venous velocity, mean venous velocity and volume flow were compared to resting values. Comfort was assessed using a 100mm non-hatched visual analogue scale taken before application of NMES, once NMES was initiated and before NMES was withdrawn. Results In the operated limb NMES produced increases in peak venous velocity of 99% compared to resting. Mean velocity increased by 178% compared to resting and volume flow increased by 159% compared to resting. In the un-operated limb, peak venous velocity increased by 288%, mean velocity increased by 354% and volume flow increased by 614% compared to basal flow (p<0.05 in all cases). There were no significant differences observed between the VAS scores taken before the application of NMES, once NMES was initiated and before NMES was withdrawn (p=.211). Conclusions NMES produces a beneficial hemodynamic response in patients in the early post-operative period following orthopaedic surgery. This patient group found extended periods of calf-muscle NMES tolerable. Trial registration ClinicalTrials.gov NCT01785251
    • Hairball--a case of mistaken identity.

      Kelly, M E; Ferede, A; Corbally, M; Our Lady's Children's Hospital, Crumlin, Dublin 12. kellym11@tcd.ie (2010-07)
      We report a classical presentation of trichobezoar in an 8 year old girl who was referred for consultation querying a probable abdominal neoplasm in the left upper quadrant. A large mobile mass was palpable in the left upper quadrant extending toward the umbilicus. Of note, she also had symptoms of recurrent abdominal pain, nausea, vomiting and halitosis. Although a rare occurrence, trichobezoar must be considered as a differential diagnosis in a patient who had a history of pica, presenting with an abdominal mass.
    • Hand injuries in foreign labour workers in an Irish university hospital.

      Sattler, Thorsten; Tobbia, Dalia; O'Shaughnessy, Michael; Department of Plastic and Hand Surgery, University Medical Centre, Freiburg, Germany; (2009)
      The present study reports on a new, rapidly growing patient subpopulation presenting with hand injuries to the Department of Plastic Surgery in Cork University Hospital (Ireland). The impact of the 10 new European Union accession states on the trauma workload is examined. The associated growth in expenditure on interpreter services is also examined. Potential risk factors in the foreign workers' new working environment is explored.
    • Handling a complaint after patient has moved.

      Boynton, Sue (Irish Dental Assocation (IDA), 2014-08)
    • Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy

      Kavanagh, David H; Savage, David A; Patterson, Christopher C; McKnight, Amy J; Crean, John K; Maxwell, Alexander P; McKay, Gareth J; the Warren 3/UK GoKinD Study Group (2013-06-18)
      Abstract Background Renal interstitial fibrosis and glomerular sclerosis are hallmarks of diabetic nephropathy (DN) and several studies have implicated members of the WNT pathways in these pathological processes. This study comprehensively examined common genetic variation within the WNT pathway for association with DN. Methods Genes within the WNT pathways were selected on the basis of nominal significance and consistent direction of effect in the GENIE meta-analysis dataset. Common SNPs and common haplotypes were examined within the selected WNT pathway genes in a white population with type 1 diabetes, discordant for DN (cases: n = 718; controls: n = 749). SNPs were genotyped using Sequenom or Taqman assays. Association analyses were performed using PLINK, to compare allele and haplotype frequencies in cases and controls. Correction for multiple testing was performed by either permutation testing or using false discovery rate. Results A logistic regression model including collection centre, duration of diabetes, and average HbA1c as covariates highlighted three SNPs in GSK3B (rs17810235, rs17471, rs334543), two in DAAM1 (rs1253192, rs1252906) and one in NFAT5 (rs17297207) as being significantly (P < 0.05) associated with DN, however these SNPs did not remain significant after correction for multiple testing. Logistic regression of haplotypes, with ESRD as the outcome, and pairwise interaction analyses did not yield any significant results after correction for multiple testing. Conclusions These results indicate that both common SNPs and common haplotypes of WNT pathway genes are not strongly associated with DN. However, this does not completely exclude these or the WNT pathways from association with DN, as unidentified rare genetic or copy number variants could still contribute towards the genetic architecture of DN.
    • Hazardous alcohol consumption among university students in Ireland: a cross-sectional study.

      Davoren, Martin P; Shiely, Frances; Byrne, Michael; Perry, Ivan J (2015)
      There is considerable evidence of a cultural shift towards heavier alcohol consumption among university students, especially women. The aim of this study is to investigate the prevalence and correlates of hazardous alcohol consumption (HAC) among university students with particular reference to gender and to compare different modes of data collection in this population.
    • Head shop compound abuse amongst attendees of the Drug Treatment Centre Board.

      McNamara, S; Stokes, S; Coleman, N; The Drug Treatment Centre Board, 30-31 Pearse St, Dublin 2. (2010-05)
      The use of "Head Shop" compounds has received much media attention lately. There is very little research in the current literature with regard to the extent of the usage of these substances amongst the drug using population in Ireland. We conducted a study to examine the extent of the usage of Mephedrone, Methylone and BZP amongst attendees of Methadone maintenance programs at the DTCB. Two hundred and nine samples in total were tested. The results showed significant usage of these compounds amongst this cohort of drug users, with 29 (13.9%) of samples tested being positive for Mephedrone, 7 (3.3%) positive for Methylone and 1 (0.5%) positive for BZP.
    • Headaches, neurologists and the emergency department

      Gaughran, G; Tubridy, N (Irish Medical Journal, 2014-06)
      This study explores the claim that headache management can be improved by evaluating current emergent care. A retrospective chart review investigated primary complaints of headache during a three-month period. Two hundred and twenty seven patients were identified for review and three-month follow-up using fully available records and imaging. A total of 543/8,759 had a neurological condition. The most common conditions were headaches (42% or 227 cases), cerebrovascular problems (26%) and seizures (17%). No ’usual headache’ patterns showed abnormal imaging. In contrast, those with ’sudden-onset’ type or clinical findings had an abnormal scan 17% of the time. Of the MRIs ordered, one-quarter changed management. On discharge, 39% of patients left without a specific headache diagnosis. In the discussion, we evaluate how well a tertiary referral ED treats its most common neurological complaint, focusing on the controversial topics of when to investigate and prevention of re-attendance.
    • Heading for a fall? Management of head injury in infants.

      Williamson, M; Keenan, P; Kuan, S; McKay, M; The Children's University Hospital, Temple St, Dublin 1. williamson2@gmail.com (2010-09)
      Head injury is one of the commonest reasons for infants (< 1 year) to attend the Emergency Department (ED). Clinical management varies considerably and concern about non accidental injury results in a high admission rate in some hospitals. Information was obtained on 103 children under one year of age presenting to the ED with head injury in a prospective study. The average age was 6.7 months and 57% of patients were male. Twenty eight babies had skull x rays with 1 skull fracture diagnosed. None required CT brain scan. Ninety eight (94%) were discharged home from the ED. There were no unplanned returns, readmissions or adverse events. The incidence of traumatic brain injury in children under one year of age presenting with head injury is low and the majority can be safely discharged home.
    • Health and social care costs of managing amyotrophic lateral sclerosis (ALS): An Irish perspective

      Connolly, Sheelah; Heslin, Chloe; Mays, Iain; Corr, Bernie; Normand, Charles; Hardiman, Orla (2014-10)
    • Health and use of health services of people who are homeless and at risk of homelessness who receive free primary health care in Dublin

      Keogh, Claire; O’Brien, Kirsty K; Hoban, Anthony; O’Carroll, Austin; Fahey, Tom (2015-02-12)
    • Health benefits of 'grow your own' food in urban areas: implications for contaminated land risk assessment and risk management?

      Abstract Compelling evidence of major health benefits of fruit and vegetable consumption, physical activity, and outdoor interaction with 'greenspace' have emerged in the past decade - all of which combine to give major potential health benefits from 'grow-your-own' (GYO) in urban areas. However, neither current risk assessment models nor risk management strategies for GYO in allotments and gardens give any consideration to these health benefits, despite their potential often to more than fully compensate the risks. Although urban environments are more contaminated by heavy metals, arsenic, polyaromatic hydrocarbons and dioxins than most rural agricultural areas, evidence is lacking for adverse health outcomes of GYO in UK urban areas. Rarely do pollutants in GYO food exceed statutory limits set for commercial food, and few people obtain the majority of their food from GYO. In the UK, soil contamination thresholds triggering closure or remediation of allotment and garden sites are based on precautionary principles, generating 'scares' that may negatively impact public health disproportionately to the actual health risks of exposure to toxins through own-grown food. By contrast, the health benefits of GYO are a direct counterpoint to the escalating public health crisis of 'obesity and sloth' caused by eating an excess of saturated fats, inadequate consumption of fresh fruit and vegetables combined with a lack of exercise. These are now amongst the most important preventable causes of illness and death. The health and wider societal benefits of 'grow-your-own' thus reveal a major limitation in current risk assessment methodologies which, in only considering risks, are unable to predict whether GYO on particular sites will, overall, have positive, negative, or no net effects on human health. This highlights a more general need for a new generation of risk assessment tools that also predict overall consequences for health to more effectively guide risk management in our increasingly risk-averse culture.
    • The health benefits of nose breathing

      Allen, Ruth (Nursing in General Practice, 2015-01)
    • Health care expenditure in Ireland: a comparitive analysis and policy issues

      Durkan, Joe; University College Dublin. Graduate School of Business. Centre for Health Economics (1994-04)
    • Health literacy and public health: A systematic review and integration of definitions and models

      Sorensen, Kristine; Broucke, Stephan VAN DEN; Fullam, James; Doyle, Gerardine; Pelikan, Jurgen; Slonska, Zofia; Brand, Helmut; (HLS-EU) Consortium, European Health Literacy Project (2012-01-25)
      Abstract Background Health literacy concerns the knowledge and competences of persons to meet the complex demands of health in modern society. Although its importance is increasingly recognised, there is no consensus about the definition of health literacy or about its conceptual dimensions, which limits the possibilities for measurement and comparison. The aim of the study is to review definitions and models on health literacy to develop an integrated definition and conceptual model capturing the most comprehensive evidence-based dimensions of health literacy. Methods A systematic literature review was performed to identify definitions and conceptual frameworks of health literacy. A content analysis of the definitions and conceptual frameworks was carried out to identify the central dimensions of health literacy and develop an integrated model. Results The review resulted in 17 definitions of health literacy and 12 conceptual models. Based on the content analysis, an integrative conceptual model was developed containing 12 dimensions referring to the knowledge, motivation and competencies of accessing, understanding, appraising and applying health-related information within the healthcare, disease prevention and health promotion setting, respectively. Conclusions Based upon this review, a model is proposed integrating medical and public health views of health literacy. The model can serve as a basis for developing health literacy enhancing interventions and provide a conceptual basis for the development and validation of measurement tools, capturing the different dimensions of health literacy within the healthcare, disease prevention and health promotion settings.