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dc.contributor.authorAnderson, Jocelyn
dc.contributor.authorGlynn, Liam G
dc.contributor.authorNewell, John
dc.contributor.authorIglesias, Alberto A
dc.contributor.authorReddan, Donal
dc.contributor.authorMurphy, Andrew W
dc.date.accessioned2010-03-08T13:08:49Z
dc.date.available2010-03-08T13:08:49Z
dc.date.issued2009
dc.identifier.citationThe impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study. 2009, 9:51 BMC Cardiovasc Disorden
dc.identifier.issn1471-2261
dc.identifier.pmid19909540
dc.identifier.doi10.1186/1471-2261-9-51
dc.identifier.urihttp://hdl.handle.net/10147/93843
dc.description.abstractBACKGROUND: The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated with milder levels of anaemia when it is present concurrently with CVD and chronic kidney disease (CKD). The aim of this study was to establish the prevalence of CKD and anaemia in patients with CVD in the community and to examine whether the presence of anaemia was associated with increased morbidity and mortality. METHODS: This study was designed as a retrospective cohort study and involved a random sample of 35 general practices in the West of Ireland. A practice-based sample of 1,609 patients with established cardiovascular disease was generated in 2000/2001 and followed for five years. The primary endpoint was death from any cause. Statistical analysis involved using one-way ANOVA and Chi-squared tests for baseline data and Cox proportional-hazards models for mortality data. RESULTS: Of the study sample of 617 patients with blood results, 33% (n = 203) had CKD while 6% (n = 37) had CKD and anaemia. The estimated risk of death from any cause, when compared to patients with cardiovascular disease only, was almost double (HR = 1.98, 95% CI 0.99 to 3.98) for patients with both CVD and CKD and was over 4 times greater (HR = 4.33, 95% CI 1.76 to 10.68) for patients with CVD, CKD and anaemia. CONCLUSION: In patients with cardiovascular disease in the community, chronic kidney disease and anaemia occur commonly. The presence of chronic kidney disease carries an increased mortality risk which increases in an additive way with the addition of anaemia. These results suggest that early primary care diagnosis and management of this high risk group may be worthwhile.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshAnemia
dc.subject.meshCardiovascular Diseases
dc.subject.meshCause of Death
dc.subject.meshChi-Square Distribution
dc.subject.meshCohort Studies
dc.subject.meshComorbidity
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIreland
dc.subject.meshKaplan-Meiers Estimate
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshProportional Hazards Models
dc.subject.meshRenal Insufficiency, Chronic
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Assessment
dc.subject.meshRisk Factors
dc.subject.meshTime Factors
dc.titleThe impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study.en
dc.contributor.departmentDepartment of General Practice, NUI Galway, Ireland. j.anderson2@nuigalway.ieen
dc.identifier.journalBMC cardiovascular disordersen
refterms.dateFOA2018-09-03T10:15:37Z
html.description.abstractBACKGROUND: The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated with milder levels of anaemia when it is present concurrently with CVD and chronic kidney disease (CKD). The aim of this study was to establish the prevalence of CKD and anaemia in patients with CVD in the community and to examine whether the presence of anaemia was associated with increased morbidity and mortality. METHODS: This study was designed as a retrospective cohort study and involved a random sample of 35 general practices in the West of Ireland. A practice-based sample of 1,609 patients with established cardiovascular disease was generated in 2000/2001 and followed for five years. The primary endpoint was death from any cause. Statistical analysis involved using one-way ANOVA and Chi-squared tests for baseline data and Cox proportional-hazards models for mortality data. RESULTS: Of the study sample of 617 patients with blood results, 33% (n = 203) had CKD while 6% (n = 37) had CKD and anaemia. The estimated risk of death from any cause, when compared to patients with cardiovascular disease only, was almost double (HR = 1.98, 95% CI 0.99 to 3.98) for patients with both CVD and CKD and was over 4 times greater (HR = 4.33, 95% CI 1.76 to 10.68) for patients with CVD, CKD and anaemia. CONCLUSION: In patients with cardiovascular disease in the community, chronic kidney disease and anaemia occur commonly. The presence of chronic kidney disease carries an increased mortality risk which increases in an additive way with the addition of anaemia. These results suggest that early primary care diagnosis and management of this high risk group may be worthwhile.


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